Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trappingN-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

1. (1S)-1-phenyl-2-(pyridin-2-yl)ethanamine (lanicemine; AZD6765) is a low-trapping N-methyl-d-aspartate (NMDA) channel blocker that has been studied as an adjunctive treatment in major depressive disorder. The metabolism and disposition of lanicemine was determined in six healthy male subjects after a single intravenous infusion dose of 150 mg [14C]-lanicemine.