催化作用
亲核细胞
氟
化学
亲核加成
氢键
有机化学
分子
作者
Jin‐Sheng Yu,Yunling Liu,Jing Tang,Xin Wang,Jian Zhou
标识
DOI:10.1002/anie.201404432
摘要
A remarkable fluorine effect on "on water" reactions is reported. The CF⋅⋅⋅HO interactions between suitably fluorinated nucleophiles and the hydrogen-bond network at the phase boundary of oil droplets enable the formation of a unique microstructure to facilitate on water catalyst-free reactions, which are difficult to realize using nonfluorinated substrates. Accordingly, a highly efficient on water, catalyst-free reaction of difluoroenoxysilanes with aldehydes, activated ketones, and isatylidene malononitriles was developed, thus leading to the highly efficient synthesis of a variety of α,α-difluoro-β-hydroxy ketones and quaternary oxindoles.
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