磷酸二酯酶3
磷酸二酯酶
第二信使系统
环磷酸鸟苷
环核苷酸
细胞生物学
细胞内
环磷酸腺苷
生物
信号转导
腺苷
生物化学
化学
内分泌学
受体
基因
酶
核苷酸
一氧化氮
作者
Tsuyoshi Murata,Kensuke Shimizu,Kenichi Hiramoto,Tetsuya Tagawa
出处
期刊:Cardiovascular and Hematological Agents in Medicinal Chemistry
[Bentham Science]
日期:2009-07-01
卷期号:7 (3): 206-211
被引量:13
标识
DOI:10.2174/187152509789105453
摘要
Cyclic adenosine 3'5'-monophosphate (cAMP) and cyclic guanosine 3'5'-monophosphate (cGMP) are critical intracellular messengers involved in transduction of signals generated by a wide variety of extracellular stimuli, including growth factors, cytokines, peptide hormones, light and neurotransmitters. These messengers modulate many fundamental biological processes, including myocardial contractility, platelet aggregation, vascular smooth muscle relaxation, proliferation and apoptosis, etc. Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP, and are important in regulating intracellular concentrations and biological actions of these signal-transducing molecules. These enzymes contain at least 11 highly regulated and structurally related gene families (PDE1-11). In this review, we will discuss some general information of PDEs and then focus on PDE3 gene family, including the molecular biology, structure, function and potential as therapeutic targets. Furthermore, we show the possibilities of PDE3 as therapeutic targets in malignant tumor cells and salivary gland.
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