BK Viremia Is Associated with Cyclophosphamide Use and Graft Versus Host Disease (GVHD) in Pediatric Hematopoietic Stem Cell Transplantation (SCT)

BK virus infection post-SCT is a common cause of hemorrhagic cystitis and is diagnosed by demonstrating virus in the urine (viruria). BK viremia, independent of viruria, was associated with renal dysfunction in our prior retrospective SCT study (Haines HL et al, BBMT, 2011). Nevertheless, post-SCT, little is known about both the prevalence of viremia and risk factors associated with BK infection. Therefore, we assessed the epidemiology of and clinical indicators for the development of post-SCT BK viremia.