西斯特
X-失活
生物
X染色体
长非编码RNA
诱导多能干细胞
剂量补偿
染色体
非编码RNA
遗传学
核糖核酸
细胞生物学
基因
胚胎干细胞
作者
Céline Vallot,Christophe Huret,Yann Lesecque,Alissa Resch,Noufϊssa Oudrhiri,Annelise Bennaceur-Griscelli,Laurent Duret,Claire Rougeulle
出处
期刊:Nature Genetics
[Springer Nature]
日期:2013-01-20
卷期号:45 (3): 239-241
被引量:123
摘要
X-chromosome inactivation (XCI) in mammals relies on XIST, a long noncoding transcript that coats and silences the X chromosome in cis. Here we report the discovery of a long noncoding RNA, XACT, that is expressed from and coats the active X chromosome specifically in human pluripotent cells. In the absence of XIST, XACT is expressed from both X chromosomes in humans but not in mice, suggesting a unique role for XACT in the control of human XCI initiation.
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