泛素连接酶
乳腺癌
细胞迁移
转移
癌症研究
下调和上调
癌症
基因敲除
生物
细胞
泛素
细胞培养
遗传学
基因
作者
Tsunehisa Kanoh,Jingyu Lu,Takamasa Mizoguchi,Motoyuki Itoh
标识
DOI:10.1016/j.bbrc.2023.05.034
摘要
Breast cancer is one of the most common invasive cancers among women. The leading cause of difficulty in treating breast cancer patients is metastasis. Because cell migration is closely related to breast cancer metastasis, elucidating the detailed mechanism by which breast cancer cells promote their migration is crucial for improving the prognosis of patients. In this study, we investigated the relationship between breast cancer cell migration and Mind bomb1 (MIB1), an E3 ubiquitin ligase. We found that the downregulation of MIB1 promotes the cell migration of MCF7, a breast cancer-derived cell line. Furthermore, knockdown of MIB1 caused a reduction in CTNND1 and thereby impaired E-cadherin membrane localization in the cell boundary region. Taken together, our data suggest that MIB1 might play a role in suppressing breast cancer cell migration.
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