棒状杆菌
失调
微生物群
脂溢性皮炎
生物
皮肤病科
头皮
厚壁菌
人口
马拉色菌
葡萄球菌
银屑病
微生物学
医学
免疫学
细菌
金黄色葡萄球菌
16S核糖体RNA
遗传学
环境卫生
作者
Kanthaporn Dityen,Wipasiri Soonthornchai,Patipark Kueanjinda,Chitrasak Kullapanich,Naruemon Tunsakul,Naraporn Somboonna,Jongkonnee Wongpiyabovorn
摘要
Seborrheic dermatitis (SD) is a chronic inflammatory skin condition that occurs in body areas that contain profuse sebaceous glands. Skin microbiota are diverse across ethnic groups and its dysbiosis has been implicated in the pathogenesis of SD. Here, we reported the contribution of cutaneous bacterial microbiota to SD in the Thai population. Healthy individuals and patients with scalp SD were recruited into the study. Normal skin, scalp skin lesion (SL) and non-lesion sites (SNL) samples were collected using a tape stripping method and next-generation sequencing of 16S rRNA for microbiome analysis. Although bacterial diversity in all sample groups was not statistically different, a population of bacteria commonly found on skin of scalp showed signs of dysbiosis. Apart from the reduction of Corynebacterium spp., SD-specific microbiota was dominated by Firmicutes at taxa level and Pseudomonas spp., Staphylococcus spp. and Micrococcus spp. at genus level. The dysbiosis of the skin microbiota in SD was specifically described as an alteration of bacteria populations commonly found on scalp skin, implying that managing and controlling the cutaneous bacterial microbiome can alleviate and prevent SD and pave the way for the development of new SD treatments.
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