医学
荟萃分析
粘膜炎
随机对照试验
科克伦图书馆
心理干预
系统回顾
入射(几何)
梅德林
内科学
重症监护医学
放射治疗
精神科
物理
光学
政治学
法学
作者
Reza Amiri Khosroshahi,Sepide Talebi,Sheida Zeraattalab-Motlagh,Hossein Imani,Amirabbas Rashidi,Nikolaj Travica,Hamed Mohammadi
出处
期刊:Nutrition Reviews
[Oxford University Press]
日期:2023-02-10
卷期号:81 (9): 1200-1212
被引量:2
标识
DOI:10.1093/nutrit/nuac105
摘要
To date, the efficacy of nutritional interventions on oral mucositis (OM) in patients with cancer, and the quality of this evidence have not been explored.The goal of this umbrella review was to provide a comprehensive evaluation of nutritional interventions for patients with cancer with OM, as well as to assess the quality of this evidence.Meta-analyses were searched for using PubMed, Scopus, and ISI Web of Science databases until December 2021, with no time restrictions.Meta-analyses of randomized control trials that evaluated the effects of nutritional interventions on the incidence of OM in patients with cancer had inclusion criteria for this umbrella review. Data extraction, quality assessment of meta-analyses, and primary studies were done independently by 2 authors. The Grading of Recommendations Assessment, Development, and Evaluation technique was used to grade the certainty of evidence.A total of 26 meta-analyses were included in this umbrella review. The results showed that honey, glutamine, and propolis can reduce the incidence of severe OM, based on moderate evidence quality. In addition, zinc supplementation significantly reduced the incidence of OM, regardless of symptom severity; however, low certainty of the evidence was observed. The effects of vitamin E, curcumin, and probiotics on OM were not statistically significant.This umbrella review shows that honey, glutamine, and propolis can significantly reduce the incidence of severe OM. These findings need to be confirmed with well-designed, longitudinal randomized controlled trials.PROSPERO registration no. CRD42022301010.
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