3‐Phenyl‐3‐(trifluoromethyl)‐3 H ‐diazirine

[73899-14-6] C 8 H 5 F 3 N 2 (MW 186.13) InChI = 1S/C8H5F3N2/c9-8(10,11)7(12-13-7)6-4-2-1-3-5-6/h1-5H InChIKey = IXEVBKYJNFWMPR-UHFFFAOYSA-N Alternative Names: 3-phenyl-3-(trifluoromethyl)diazirine, 3-phenyl-3-trifluoromethyl-3 H -diazirine, 3-trifluoromethyl-3-phenyldiazirine. Solubility: soluble in most organic solvents. 1,2 Physical Data: bp 176.4 °C at 760 mmHg. Form Supplied in: liquid. Preparative Methods: commercially available; can be prepared from trifluoromethylacetophenone. 3–5 Handling, Storage, and Precautions: 3-phenyl-3-(trifluoromethyl)-3 H -diazirine can be stored in the dark at room temperature for weeks or heated to 75 °C for at least 0.5 h with little or no observable degradation. Solutions of the compound in methanol containing 1 M HCl or 1 M NaOH are stable at room temperature for at least 2 h. 3 Furthermore, the title compound is inert toward mild reductants, oxidants, bases, acids, and Lewis acids. While no explosions of the title compound have been reported, it is advised to handle this reagent with caution, 2,6 due to reported explosivity of other diazirines. 7