Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne

ABSTRACT Background Acne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement. Objective This study aimed to explore the clinical efficacy and safety of botulinum toxin A combined with hyaluronic acid in improving facial pore enlargement. Method A retrospective study was conducted on 40 acne patients with enlarged pores. Botulinum toxin A and non‐cross‐linked hyaluronic acid compound were injected into the patient's face using mesotherapy with nine 32‐gauge microneedles. VISIA was used to record the conditions of facial pores, texture, and porphyrins. The physician's assessment of the improvement score and the patient satisfaction evaluation are used to evaluate the treatment effect. Result One month after treatment, the combination of botulinum toxin and non‐cross‐linked hyaluronic acid compound significantly improved facial pore enlargement. Although the effects decreased, the conditions of facial pores, texture, and porphyrins 4 months after treatment still had a significant difference from those at baseline. Conclusion The combination of botulinum toxin A and non‐cross‐linked hyaluronic acid compound is safe and effective in treating enlarged pores, indicating its promotional value.