Nervonic acid mitigates IMQ-triggered psoriasis in mice via inhibiting Th17/γδT17 cell invasion and modulating the gut microbiota

银屑病 20立方厘米 炎症 免疫系统 生物 免疫学 体内 趋化因子 肠道菌群 癌症研究 趋化因子受体 生物技术
作者
Zishan Yang,Xiaorong Geng,Shenglan Zhang,Junjie Gao,Feng Ji,Yuxing Han,Zhi‐Hao Cui,Xia Wang,Sheng Guo,Dong Yan,Tiesuo Zhao,Feng Ren,Xueshi Li,Jie Dong,Zhongwei Tian,Zhinan Yin,Xiangfeng Song
出处
期刊:Journal of Leukocyte Biology [Oxford University Press]
标识
DOI:10.1093/jleuko/qiaf070
摘要

Abstract Psoriasis is a persistent immune-mediated inflammatory dermatosis. The treatment of psoriasis now features natural medicine as an effective new alternative because of its notable effectiveness and few side effects. Nervonic acid (NA), a long-chain fatty acid mostly sourced from the seed oils of some wild plants, exhibits significant antidepressant and anti-inflammatory properties. Nonetheless, the pathogenic effects and mechanism of NA in the pathogenesis of psoriasis are unreported. This work demonstrated that NA markedly mitigated IMQ-triggered psoriasis-like skin inflammation and reduced the mRNA expression levels of chemokines (Cxcl1 and Ccl20) and inflammatory factors (S100a8, S100a9, IL-17, and IL-6) both in vitro and in vivo. Mechanistically, NA blocked the IL-17/IMQ-induced NF-κB and p38MAPK signaling pathways in keratinocytes or tissue lesions, downregulated Ccl20 production, and therefore disrupted positive inflammatory feedback by diminishing Th17 or γδT17 cell infiltration. Furthermore, 16s rRNA sequencing demonstrated that NA therapy significantly elevated the relative abundance of Bacteroidota, but the outcome for Mucispirillum was contrary within the gut microbiota. These bacteria are linked to the onset of psoriasis and inflammation, perhaps contributing to the alleviation of IMQ-induced lesions in mice. In conclusion, NA may alleviate dermatitis in psoriatic mice by inhibiting Th17/γδT17 cell invasion and modulating the gut microbiota. Consequently, NA stands as a highly promising choice for psoriasis treatment.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wu-sang发布了新的文献求助10
1秒前
汤姆发布了新的文献求助30
1秒前
琪凯定理发布了新的文献求助10
3秒前
5秒前
6秒前
华桦子完成签到 ,获得积分10
6秒前
老木虫发布了新的文献求助10
9秒前
搞怪映秋发布了新的文献求助10
10秒前
10秒前
10秒前
11秒前
科研轮回发布了新的文献求助10
11秒前
ziwei完成签到,获得积分10
12秒前
123完成签到,获得积分20
12秒前
14秒前
小马甲应助怕孤单的安蕾采纳,获得10
15秒前
包包糖在摸鱼完成签到 ,获得积分10
15秒前
琪凯定理完成签到,获得积分10
16秒前
美丽沛春发布了新的文献求助10
16秒前
123发布了新的文献求助10
16秒前
Tong发布了新的文献求助10
16秒前
打打应助Matthew采纳,获得10
18秒前
棕熊熊发布了新的文献求助10
19秒前
wst发布了新的文献求助10
19秒前
勤恳完成签到,获得积分10
19秒前
笨笨晓蓝完成签到,获得积分20
21秒前
siso完成签到,获得积分10
21秒前
King完成签到,获得积分10
22秒前
Akim应助lizhi采纳,获得30
22秒前
隐形曼青应助老木虫采纳,获得10
22秒前
ballball233完成签到 ,获得积分10
23秒前
梅赛德斯奔驰完成签到,获得积分10
23秒前
Akim应助wst采纳,获得10
25秒前
zxx关注了科研通微信公众号
29秒前
29秒前
所所应助wu-sang采纳,获得10
31秒前
汤姆完成签到,获得积分10
31秒前
丘比特应助cdercder采纳,获得10
33秒前
xwl9955完成签到 ,获得积分10
34秒前
小吕完成签到,获得积分20
34秒前
高分求助中
Applied Survey Data Analysis (第三版, 2025) 800
Narcissistic Personality Disorder 700
Assessing and Diagnosing Young Children with Neurodevelopmental Disorders (2nd Edition) 700
Handbook of Experimental Social Psychology 500
The Martian climate revisited: atmosphere and environment of a desert planet 500
Transnational East Asian Studies 400
Towards a spatial history of contemporary art in China 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3845801
求助须知:如何正确求助?哪些是违规求助? 3388159
关于积分的说明 10551960
捐赠科研通 3108790
什么是DOI,文献DOI怎么找? 1713127
邀请新用户注册赠送积分活动 824592
科研通“疑难数据库(出版商)”最低求助积分说明 774908