Electrochemical Lattice Engineering of Bismuthene for Selective Glycine Synthesis

Abstract Glycine plays a crucial role in various industrial and daily applications. However, traditional synthesis methods are often associated with high toxicity, energy intensity, and inefficiency. This study introduces an efficient and eco‐friendly method for synthesizing glycine via the reductive coupling of oxalic acid and nitrate using a Bi metal catalyst, enhanced by lattice strain from Bi and oxide composites undergoing electrochemical transformation. At an applied potential of −0.76 V versus the reversible hydrogen electrode (RHE), the Bi catalyst achieves an impressive glycine Faradaic efficiency (FE) of 79.1%, yielding a record concentration of 0.17 m , substantially higher than conventional Bi‐based systems. Furthermore, the introduction of glycolaldehyde and hydroxylamine as reactants raise the glycine FE to 91.3% with a production rate of 2433.3 µmol h −1 under identical conditions. Electrochemical analysis and theoretical calculations demonstrate that lattice expansion notably boosts glycine synthesis by facilitating NH 2 OH formation and promoting the efficient reduction of oxime intermediates. These results underscore the significance of lattice engineering in enhancing active site performance and accelerating reaction kinetics, offering a sustainable and efficient alternative to traditional glycine synthesis methods.