Autism spectrum disorders and the volume of the striatum and Amygdala: A Mendelian randomization study

The putamen's change rate appears to be a significant change caused by ASD which may be a strong predictive capability for ASD risk, while the amygdala's change rate and GM of striatum and amygdala volume does not show a significant predictive capability in this context. The present study provides evidence of a genetic relationship between ASD and putamen volume. Further investigation is required to elucidate the mechanisms underlying the genetic effect of changes in putamen structure and function on ASD.