金鸡纳
铱
生物碱
催化作用
化学
配体(生物化学)
有机化学
不对称氢化
对映选择合成
受体
生物化学
作者
Qian Xu,Wenchang Gou,Ping Dai,Xuan Zhou,Jie Tian,Xiangtai Meng,Yu Tian,Lin Zhang,Chun Li
标识
DOI:10.1021/acs.joc.3c02032
摘要
The Ir-catalyzed asymmetric hydrogenation of β-keto esters with Cinchona-alkaloid-derived NNP ligands has been developed. β-Hydroxy esters of opposite configuration were afforded smoothly with 91.5-99.1 and 81.6-99.3% ee, respectively, using NNP L2 and L7 derived from quinidine and quinine separately even on the gram scale. The protocol for the preparation of β-hydroxy esters of opposite configuration by the simple conversion of ligand configurations offered further opportunities for the synthesis of biologically active molecules and drugs.
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