Cryptic Peptides Encoded by Tumor-Specific Circular RNA Are Immunogenic

Major Finding: Cryptic antigenic peptides encoded by tumor-specific circular RNA (circRNA) induce antitumor immunity. Concept: Vaccines that use tumor-specific circRNA-encoded cryptic antigenic peptides reduce tumor progression. Impact: Therapeutic use of vaccines that exploit tumor-specific circRNAs can be an effective antitumor strategy.