溶酶体
适体
细胞生物学
降级(电信)
链霉亲和素
纳米技术
蛋白质降解
化学
靶蛋白
生物物理学
生物
材料科学
分子生物学
生物化学
生物素
计算机科学
基因
酶
电信
作者
Qiao Duan,Hao‐Ran Jia,Weichang Chen,Qin Cui,Kejing Zhang,Fei Jia,Ting Fu,Yong Wei,Mengyang Fan,Qin Wu,Weihong Tan
标识
DOI:10.1002/advs.202308924
摘要
Selective protein degradation platforms have opened novel avenues in therapeutic development and biological inquiry. Antibody-based lysosome-targeting chimeras (LYTACs) have emerged as a promising technology that extends the scope of targeted protein degradation to extracellular targets. Aptamers offer an advantageous alternative owing to their potential for modification and manipulation toward a multivalent state. In this study, a chemically engineered platform of multivalent aptamer-based LYTACs (AptLYTACs) is established for the targeted degradation of either single or dual protein targets. Leveraging the biotin-streptavidin system as a molecular scaffold, this investigation reveals that trivalently mono-targeted AptLYTACs demonstrate optimum efficiency in degrading membrane proteins. The development of this multivalent AptLYTACs platform provides a principle of concept for mono-/dual-targets degradation, expanding the possibilities of targeted protein degradation.
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