Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles

While elevated mtCa²⁺ disrupted cardiac function in both ventricles, it induced an LV-specific adaptive response that suppressed mtCa²⁺ intake, contributing to the recovery of mitochondrial and cardiac function. The absence of this pathway in the RV has implications for therapeutics targeting RV dysfunction, a key determinant of mortality in heart failure.