Copper(II)‐Catalyzed Regioselective Cascade Reaction of β,γ‐Alkynyl‐α‐Imino Esters with α‐Amino Acid‐Derived Esters

Abstract A cascade reaction between β,γ‐alkynyl‐α‐imino esters and α‐amino acid‐derived esters has been developed, enabling the efficient synthesis of a series of novel α‐amino acid derivatives featuring oxazolone moieties under mild reaction conditions. Control experiments and mechanistic studies were conducted to elucidate the reaction pathway and gain insights into the underlying process.