连续血糖监测
可穿戴计算机
血糖自我监测
低血糖
糖尿病管理
医学
糖尿病
持续监测
重症监护医学
计算机科学
生物医学工程
1型糖尿病
2型糖尿病
运营管理
嵌入式系统
工程类
内分泌学
作者
Jian Yang,Xia Gong,Shuijin Chen,Ying Zheng,Lelun Peng,Bin Liu,Zhipeng Chen,Xi Xie,Changqing Yi,Lelun Jiang
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2023-02-23
卷期号:8 (3): 1241-1251
被引量:20
标识
DOI:10.1021/acssensors.2c02635
摘要
Continuous glucose monitoring (CGM) can mini-invasively track blood glucose fluctuation and reduce the risk of hyperglycemia and hypoglycemia, and this is is in great demand for diabetes management. However, cost-effective manufacture of CGM systems with continuously improved convenience and performance is still the persistent goal. Herein, we developed a smartphone-controlled and microneedle (MN)-based wearable CGM system for long-term glucose monitoring. The CGM system modified with a sandwich-type enzyme immobilization strategy can satisfy the clinical requirement of interstitial fluid (ISF) glucose monitoring for 14 days with a mean absolute relative difference of 10.2% and a cost of less than $15, which correlated well with the commercial glucometer and FDA-approved CGM system FreeStyle Libre (Abbott Inc., Illinois, USA). The self-developed CGM system is demonstrated to accurately monitor glucose fluctuations and provide abundant clinical information. It is better to find the cause of individual blood glucose changes and beneficial for the guide of precise glucose control. On the whole, the intelligently wearable CGM system may provide an alternative solution for home-care diabetes management.
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