特应性皮炎
氧化应激
材料科学
皮肤病科
纳米技术
医学
内科学
作者
Yuanyuan Zhang,Xiaoxuan Zhang,Xiangyi Wu,Yuanjin Zhao
出处
期刊:Nano Today
[Elsevier]
日期:2024-06-01
卷期号:56: 102241-102241
标识
DOI:10.1016/j.nantod.2024.102241
摘要
As a common chronic inflammatory skin disease, atopic dermatitis (AD) troubles many people, while its effective therapy is a challenge. Here, we present novel polydopamine (PDA) nanoenzyme integrated near-infrared ray (NIR)-responsive microneedles (MNs) with antioxidant capacity for AD treatment. Such MNs are composed of a hyaluronic acid (HA) backing layer and hyaluronic acid methacrylate (HAMA) tips that are loaded with PDA nanoenzyme. Owing to the photo-thermal conversion capability of PDA nanoenzyme, the MNs can enhance local microcirculatory blood flow, inhibit bacterial growth, and consequently alleviate inflammation and facilitate lesion repair. Besides, the antioxidant properties of PDA nanoparticles could markedly reduce the ROS production in HaCaT cells under conditions of elevated oxidative stress. Based on these features, we have demonstrated that the MNs could effectively realize remission in AD mouse models. Thus, we believe that the proposed NIR-responsive PDA nanoenzyme MNs could serve as a promising therapeutic approach for the treatment and management of clinic AD.
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