医学
孟德尔随机化
肠易激综合征
内科学
逻辑回归
比例危险模型
队列
疾病
帕金森病
前瞻性队列研究
队列研究
随机化
单变量分析
多元分析
随机对照试验
基因型
遗传变异
基因
生物化学
化学
作者
Zhiyun Wang,Dongrui Ma,Meng-jie Li,Yuanyuan Liang,Z. W. Hu,Shuangjie Li,Chun-yan Zuo,Chuangli Hao,Yuanming Feng,Mengnan Guo,Xiaoyan Hao,Yuanli Guo,Ke Ma,Lanwei Guo,Chan Zhang,Yuming Xu,Chengyuan Mao,Changhe Shi
出处
期刊:npj Parkinson's disease
日期:2024-03-28
卷期号:10 (1)
标识
DOI:10.1038/s41531-024-00691-5
摘要
This study aimed to investigate the association between irritable bowel syndrome (IBS) and Parkinson's disease (PD) utilizing prospective cohort study and Mendelian randomization. The dataset contained a substantial cohort of 426,911 participants from the UK Biobank, discussing the association between IBS and PD with Cox proportional hazards models and case-control analysis while adjusting for covariates such as age, gender, ethnicity and education level. In univariate Cox regression model, the risk of PD was reduced in IBS patients (HR: 0.774, 95%CI: 0.625-0.956, P = 0.017), but the statistical significance diminished in the three models after adjusting for other variables. In a few subgroup analyses, IBS patients are less likely to develop into PD, and patients diagnosed with IBS after 2000 also had a lower risk (HR: 0.633, 95%CI: 0.403-0.994, P = 0.047) of subsequently developing PD. In addition, we matched five healthy control participants based on gender and age at the end of the study for each IBS patient diagnosed during the follow-up period, and logistic regression results (OR:1.239, 95%CI: 0.896-1.680, P = 0.181) showed that IBS was not associated with the risk of PD. Mendelian randomization did not find significant evidence of the causal relationship between IBS and Parkinson's disease (OR: 0.801, 95%CI: 0.570-1.278, P = 0.204). Overall, we suggest that IBS status is not associated with the risk of developing PD, and that these findings provide valuable insights into the clinical management and resource allocation of patients with IBS.
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