Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton

Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8+ T cells that result in the recruitment and local activation of M1-like macrophages. Cancer immunotherapy is a pillar of clinical oncology but only achieves long-term remissions in a minority of cases. In this issue, van Elsas et al. show that effective immunotherapy requires a series of processes orchestrated by CD8+ T cells that result in the recruitment and local activation of M1-like macrophages. Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacyvan Elsas et al.Cancer CellMay 16, 2024In Briefvan Elsas et al. demonstrate that immunotherapy-induced intratumoral CD8+ T cells attract macrophages into their close vicinity via CCR5-signaling and subsequently differentiate them toward a late-stage activated M1-like phenotype. These macrophages play a crucial role in effective tumor control in mouse models and are correlated to clinical responses in humans. Full-Text PDF Open Access