The dangerous liaison between epicardial adipose tissue and heart failure with preserved ejection fraction

European Journal of Heart FailureVolume 24, Issue 12 p. 2261-2263 Invited Editorial The dangerous liaison between epicardial adipose tissue and heart failure with preserved ejection fraction Nicolò De Biase, Nicolò De Biase Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySearch for more papers by this authorLavinia Del Punta, Lavinia Del Punta Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySearch for more papers by this authorNicola Riccardo Pugliese, Corresponding Author Nicola Riccardo Pugliese [email protected] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Corresponding author. Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy. Tel/Fax: +39 050 992409, Email: [email protected]Search for more papers by this author Nicolò De Biase, Nicolò De Biase Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySearch for more papers by this authorLavinia Del Punta, Lavinia Del Punta Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySearch for more papers by this authorNicola Riccardo Pugliese, Corresponding Author Nicola Riccardo Pugliese [email protected] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Corresponding author. Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy. Tel/Fax: +39 050 992409, Email: [email protected]Search for more papers by this author First published: 14 November 2022 https://doi.org/10.1002/ejhf.2733Citations: 1 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.2709 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1Pugliese NR, Paneni F, Mazzola M, de Biase N, del Punta L, Gargani L, et al. Impact of epicardial adipose tissue on cardiovascular hemodynamics, metabolic profile, and prognosis in heart failure. Eur J Heart Fail. 2021; 23: 1858– 71. 2Tromp J, Bryant JA, Jin X, van Woerden G, Asali S, Yiying H, et al. Epicardial fat in heart failure with reduced versus preserved ejection fraction. Eur J Heart Fail. 2021; 23: 835– 8. 3Koepp KE, Obokata M, Reddy YNV, Olson TP, Borlaug BA. Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction. JACC Heart Fail. 2020; 8: 657– 66. 4 Pugliese NR, Pellicori P, Filidei F, de Biase N, Maffia P, Guzik TJ, et al. Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions. Cardiovasc Res. 2022. https://doi.org/10.1093/cvr/cvac133 5Iacobellis G. Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol. 2015; 11: 363– 71. 6 Nesti L, Pugliese NR, Chiriacò M, Trico D, Baldi S, Natali A. Epicardial adipose tissue thickness is associated with reduced peak oxygen consumption and systolic reserve in patients with type 2 diabetes and normal heart function. Diabetes Obes Metab. 2023; 25: 177– 88. 7Packer M, Lam CSP, Lund LH, Maurer MS, Borlaug BA. Characterization of the inflammatory-metabolic phenotype of heart failure and a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease. Eur J Heart Fail. 2020; 22: 1551– 67. 8 Venkateshvaran A, Faxen UL, Hage C, Michaëlsson E, Svedlund S, Saraste A, et al. Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS-HFpEF study. Eur J Heart Fail. 2022; 24: 2251– 60. 9Pugliese NR, Biase N, Balletti A, Filidei F, Pieroni A, D'Angelo G, et al. Characterisation of haemodynamic and metabolic abnormalities in the heart failure spectrum: the role of combined cardiopulmonary and exercise echocardiography stress test. Minerva Cardiol Angiol. 2021; 70: 370– 84. 10Pugliese NR, Fabiani I, Santini C, Rovai I, Pedrinelli R, Natali A, et al. Value of combined cardiopulmonary and echocardiography stress test to characterize the haemodynamic and metabolic responses of patients with heart failure and mid-range ejection fraction. Eur Heart J Cardiovasc Imaging. 2019; 20: 828– 36. 11Pugliese NR, Mazzola M, Fabiani I, Gargani L, de Biase N, Pedrinelli R, et al. Haemodynamic and metabolic phenotyping of hypertensive patients with and without heart failure by combining cardiopulmonary and echocardiographic stress test. Eur J Heart Fail. 2020; 22: 458– 68. 12Pugliese NR, de Biase N, Conte L, Gargani L, Mazzola M, Fabiani I, et al. Cardiac reserve and exercise capacity: insights from combined cardiopulmonary and exercise echocardiography stress testing. J Am Soc Echocardiogr. 2021; 34: 38– 50. 13Pugliese NR, de Biase N, Gargani L, Mazzola M, Conte L, Fabiani I, et al. Predicting the transition to and progression of heart failure with preserved ejection fraction: a weighted risk score using bio-humoural, cardiopulmonary, and echocardiographic stress testing. Eur J Prev Cardiol. 2020; 28: 1650– 61. 14Pugliese NR, Balletti A, Armenia S, de Biase N, Faita F, Mengozzi A, et al. Ventricular-arterial coupling derived from proximal aortic stiffness and aerobic capacity across the heart failure spectrum. JACC Cardiovasc Imaging. 2022; 15: 1545– 59. 15Sorimachi H, Obokata M, Takahashi N, Reddy YNV, Jain CC, Verbrugge FH, et al. Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction. Eur Heart J. 2021; 42: 1595– 605. Citing Literature Volume24, Issue12December 2022Pages 2261-2263 ReferencesRelatedInformation