医学
结直肠癌
背景(考古学)
鸟苷酸环化酶2C
精密医学
肿瘤科
癌症
胃肠道癌
内科学
个性化医疗
生物信息学
癌症研究
受体
病理
鸟苷酸环化酶
生物
古生物学
作者
Adi Caspi,Ariana A Entezari,Madison Crutcher,Adam E. Snook,Scott A. Waldman
出处
期刊:Personalized Medicine
[Future Medicine]
日期:2022-09-01
卷期号:19 (5): 457-472
被引量:3
标识
DOI:10.2217/pme-2022-0026
摘要
Colorectal cancer remains a major cause of mortality in the USA, despite advances in prevention and screening. Existing therapies focus primarily on generic treatment such as surgical intervention and chemotherapy, depending on disease severity. As personalized medicine and targeted molecular oncology continue to develop as promising treatment avenues, there has emerged a need for effective targets and biomarkers of colorectal cancer. The transmembrane receptor guanylyl cyclase C (GUCY2C) regulates intestinal homeostasis and has emerged as a tumor suppressor. Further, it is universally expressed in advanced metastatic colorectal tumors, as well as other cancer types that arise through intestinal metaplasia. In this context, GUCY2C satisfies many characteristics of a compelling target and biomarker for gastrointestinal malignancies.Colorectal cancer is a leading cause of death in the USA. In recent years, there has been a shift in the field of oncology from generic treatments, such as surgery and chemotherapy, to personalized molecular therapies, which focus on targeting specific attributes of each patient's unique cancer. Guanylyl cyclase C is a receptor expressed in the intestinal tract, where it regulates fluid secretion and prevents tumor formation. Beyond its function in the healthy intestine, it is expressed in colorectal tumors, and other types of cancer, where it regulates transformation. Therefore, guanylyl cyclase C can serve as a useful target in cancer for prevention and therapy, as well as a marker for tumor cell detection.
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