Dynamic Change of Serum Matrix Metalloproteinase-12 after Thrombolysis in Acute Myocardial Infarction and Its Clinical Significance

Objective To investigate the dynamic change in serum matrix metalloproteinase-12(MMP-12) after thrombolysis in acute myocardial infarction(AMI) and explore its clinical significance.Methods Blood samples were collected from 60 cases of AMI before thrombolysis and 6h,24h,72h and 7d after thrombolysis.The serum MMP-12 levels of 60 cases of AMI and 18 cases of normal people(normal coronary arteriography) were measured,and at the same time,the serum MMP-12 levels of success thrombolysis group and non-success thrombolysis group were measured.Results The expression of serum MMP-12 at different periods after thrombolysis in AMI was higher than that of the normal people,and the highest level was at 72h after thrombolysis.The expression of the serum MMP-12 at 6h,24h,72h and 7d after thrombolysis in the success thrombolysis group was lower than that in the non-success thrombolysis group as if the highest level was ahead of schedule.Conclusion The expression of serum MMP-12 after thrombolysis in AMI shows dynamic change and reaches a peak at 72h after thrombolysis.The peak level of the serum MMP-12 in the success thrombolysis group seems ahead of schedule.The thrombolysis therapy has an effect on the serum MMP-12 expression.