Fentanyl combined with midazolam or propofol for colonoscopy in elderly

Objective To evaluate the sedative and analgesic effect and the safety of fentanyl combined with midazolam or propofol for colonoscopy in elderly patients.Methods Eighty elderly patients were randomly divided into 2 groups: midazolam-fentanyl group(Group MF) and propofol-fentanyl group(Group PF);colonoscopy was undergone by one doctor.The effect of sedation and analgesia,operation time,the reaction of patients,the blood pressure(MBP),oxygen saturation value(SpO2),and pulse and breath rates were observed.Results Analgesic and sedative effect were satisfactory in two groups.But Group PF was better than Group MF(P 0.05).The operation time was shorter in Group MF[(6.7 ± 1.6)min] than in Group PF[(9.2 ± 1.1)min].Patients showed a high percentage of comfort in two groups(Group MF 9.4 ± 0.5,Group PF 9.7 ± 0.3,P 0.05).During operation,MBP,SpO2,and pulse were significantly lower in Group PF than in Group MF.Con-clusion fentanyl-propofol or midazolam-fentany is effective in colonoscopy of elderly patients,but fentanyl-propofol is safer and superior to midazolam-fentang in the procedure.