Analysis on Clinical Characteristics of Primary Hepatocellular Carcinoma with or Without Cirrhosis

Objective: To investigate the clinical characteristics of HCC with and without liver cirrhosis. Methods: Two hundreds and eighty-one patients with cirrhosis and 147 patients without cirrhosis were studied in terms of the clinical symptoms, and signs and laboratory parametes. Results: The development of HCC with cirrhosis were more insidiously and the prevalence of HbsAg in HCC patients with cirrhosis was significantly higher than in those without cirrhosis (85.1% vs 67.3%, P0.01), AFP and AST were elevated in more patients with cirrhosis than those without cirrhosis (P0.05). Conclusion: The HCC with cirrhosis is more significantly associated with HBV infection than those without cirrhosis. Monitoring serum AFP is useful for cancer detection in patients with cirrhosis, however for those patients without cirrhosis, early ultrasound is more important.