Objective:To study the clinical effects of two different intravenous-inhalant combined anesthesia for ophthalmic surgery.Methods:Eighty patients scheduled for selective ophthalmic surgery under general anesthesia were randomly divided into A, B group(n=40). Patients in group A were received isoflurane inhalation and continuous infusion propofol for maintaining anesthesia; whereas patients in group B were received isoflurane inhalation and continuous infusion mixture of propofol/fentanyl. The patients′ hemodynamics, plasma glucose were monitored. The complications during recovery of two groups were also recorded.Results:In Group A, when main operating procedure started, SBPDBPHR increased significantly(P0.05), whereas in Group B, SBPDBPHR showed no obvious changes. In Group A, the plasma glucose increased as operation went on, and amount to 12.1 mmol/l due to main operating procedure(vs before induction, P0.01). In Group B, the plasma glucose was stable after induction. The emergence time of Group A and Group B were 18.5 min and 13.5 min respectively(P0.05). The incidences of complications of Group A were significantly higher than those of Group B.Conclusions:Propofol-fentanyl-isoflurane intravenous-inhalant combined anesthesia was a good choice for ophthalmic surgery.