Incompatibility of Water-Soluble Contrast Media and Intravascular Pharmacologic Agents

Kim SH, Lee HK, Han MC. Incompalibility of water-soluble contrast media and intravascular pharmacologic agents: an in vitro study. Invest Kadiol 1992;27:45–49. In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with diatrizoate sodium, diatrizoate meglumine, ioxaglate, and iothalamate; diatrizoate meglumine with diazepam and meperidine hydrochloride; and diatrizoate sodium with meperidine hydrochloride. There were no incompatibilities when the pharmacologic agents investigated were mixed with ioxithalamate, iopromide, iopamidol, and iohexol.