Roles of myeloid-derived suppressor cells in sepsis

Myeloid-derived suppressor cells are a heterogenous population of immature myeloid cells characterized by surface expression of myeloid lineage markers GR-1 and CD11b,and by their remarkable ability to suppress T-cell responses and innate immunity.Although myeloid-derived suppressor cells were originally studied and are best known for their role in tumor immune evasion and promotion of metastasis,much attention to their roles in other pathological conditions such as trauma,inflammation,autoimmune disease,and sepsis as well.This review provides a comprehensive summary of the recent literatures on the roles of myeloid-derived suppressor cells and the potential therapeutic benefits targeting them in sepsis.