The mild spatial cognitive impairment in middle-aged Kunming mice

In the present study,the difference of the spatial cognitive ability in young and middle-aged Kunming mice in Morris water maze(MWM) and six-arm water maze(RAWM) was explored.The results indicated that the cognitive abilities of both 12.5 months and 5 months old Kunming mice were affected by day,i.e.,the performance improved as days followed.Compared to 5-month old mice,the 12.5-month old mice performed badly in the RAWM,however,there was no significant difference between them in the MWM.It was suggested that the mild cognitive ability impairment of Kunming mice occurred as early as 12.5 months.Moreover,it had better to select RAWM rather than MWM to explore the mild cognitive ability impairment in the mice.