The clinical study of combined hemodialysis-hemoperfusion in chronic uremia

Objective To investigate the effect and safety of combined hemodialysis-resin hemoperfusion in uremia.Methods 26 uremia patients were treated with combined hemodialysis-resin hemoperfusion.Middle molecular subatances(MMS),urea and creatinine were detected before and after the treatment.Meanwhile,we compared the effect of combined hemodialysis-resin hemoperfusion procedure with conventional hemodialysis in uremic toxin clearance.Results MMS was reduced significantly in combined hemodialysis-hemoperfusion procedure(P0.001).Compared with conventional hemodialysis,a combination of hemoperfusion and hemodialysis had a better effect in MMS clearance(P0.001).Meanwhile,some clinical conditions(appetite,pruritus,insomnia) improved.We did not found any adverse effect.Conclusion Resin hemoperfusion can effectively clean MMS and was confirmed to be a safe and risk-free procedure.