Study of Nerve Protection by Sucrose Esters from Polygala Tenuifolia and Preliminary Structure Activity Relationship

Objective To study nerve protection by sucrose esters of Polygala tenuifolia Wild.and discuss the preliminary structure-activity relationship.Methods The nerve protection property of sucrose esters was evaluated using MTT assay and BrdU mark method.Results Tenifoliside A,tenuifo-liose J,tenuifolioses A,1-o-(E)-Benzoyl-[3-o-(E)-Alphatolluyl]-β-D-fructofu-ranosy-(2→1)-[β-D-glucopyranosyl-(1→2)]-α-D-glucopyranosid showed dose-dependent protection activites on SH-SY5Y cells from the lesion done by corticosterone.Couclusion Some of the sucrose esters from Polygala tenuifolia Wild.can protect SH-SY5Y nerve cells exposed to corticosterone.The amount of protection depends on the compound type,concentration,structrure of the nucleus and location of substituents.