Objective Our retrospective study was aimed to analyzed the risk factors of postoperative recurrence for elderly patients with colorectal cancer. Methods Clinical data of colorectal cancer patients received surgery treatment at our hospital from 2003 to 2008 was retrospectively analyzed. Results A total of 325 patients were analyzed,the rate of postoperative recurrence was 25. 23%( 82 /325). Cox regression analysis showed that T3-T4 perioperative( P = 0. 015),blood transfusion( P =0. 032),lymph node metastasis( P = 0. 018) and blood vessel invasion( P = 0. 026) were the independent risk factors of recurrence after surgery treatment in five years for elderly patients with colorectal cancer. Conclusion Recurrence of high-risk groups of follow-up work was expected to early detection of recurrence and timely intervention.