Inhibition of Histamine Whealing in Human Skin by Pyribenzamine Hydrochloride Using Iontophoretic Technique

Using the iontophoretic technics it was observed that pyribenzamine hy-drochloride inhibited histamine wheal formation in the human skin whereas sodium chloride, ephedrine hydrochloride, ephedrine sulphate and procaine hydrochloride failed to produce this effect in the concentrations used.