Role of Direct Immunofluorescence in Cutaneous Small-Vessel Vasculitis: Experience From a Tertiary Center

血管炎 医学 紫癜(腹足类) 可触紫癜 活检 过敏性紫癜 病理 病因学 皮肤活检 皮肤病科 疾病 生物 生态学
作者
Khushboo Lath,Debajyoti Chatterjee,Uma Nahar Saikia,Biman Saikia,Ranjana W. Minz,Dipankar De,Sanjeev Handa,Bishan Radotra
出处
期刊:American Journal of Dermatopathology [Lippincott Williams & Wilkins]
卷期号:40 (9): 661-666 被引量:35
标识
DOI:10.1097/dad.0000000000001170
摘要

Abstract: Skin is commonly affected by vasculitic process and often subjected to biopsy. Cutaneous vasculitis can be either primary or part of a systemic vasculitic process. This study was conducted to evaluate the diagnostic utility of direct immunofluorescence (DIF) in determination of etiology of cutaneous vasculitis. All histologically proven cases of cutaneous vasculitis over the past two and half years were retrospectively analyzed along with their clinical and DIF findings (IgG, IgA, IgM, and C3). Within this study period, a total of 198 cases of small-vessel vasculitis were diagnosed based on skin biopsy and DIF findings. The mean age of patients was 31.2 years (range 1–84 years) with slight male dominance (M:F ratio 1.06:1). Henoch–Schonlein purpura/IgA vasculitis was the commonest clinical diagnosis (31%), followed by urticarial vasculitis (11%) and others. Idiopathic vasculitis was suspected in 33% cases. Overall, DIF was positive in 60% (119/198) cases, with vascular deposition of IgA being commonest, followed by C3. The clinical diagnosis of Henoch–Schonlein purpura could be confirmed in 61.5% (40/65) cases by DIF, whereas another 20 unsuspected cases were picked up as IgA vasculitis based on DIF findings. DIF findings confirmed lupus vasculitis in 50% cases. Other cases showed variable nonspecific deposition of C3 and IgM in 42% cases. DIF can be highly useful to classify cutaneous vasculitis, with maximum efficacy for diagnosis of IgA vasculitis and lupus vasculitis. It can aid in the accurate diagnosis even when the histological changes are minimal. All cases of suspected cutaneous vasculitis should be subjected to DIF.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
科研通AI5应助小林神采纳,获得10
2秒前
JasonSun完成签到,获得积分10
2秒前
Anna爱学习发布了新的文献求助10
2秒前
lezongyang发布了新的文献求助10
4秒前
5秒前
科研通AI5应助seraphmay采纳,获得10
6秒前
shadow完成签到,获得积分10
7秒前
李爱国应助沉静白翠采纳,获得10
7秒前
冷眸完成签到 ,获得积分10
9秒前
陈瑞娟完成签到 ,获得积分10
9秒前
9秒前
啦啦啦发布了新的文献求助10
10秒前
认真的不评完成签到,获得积分10
11秒前
烟花应助晴朗采纳,获得10
12秒前
13秒前
思源应助Panchael采纳,获得10
14秒前
xiaofeiyan完成签到 ,获得积分10
15秒前
John完成签到,获得积分10
15秒前
star发布了新的文献求助10
16秒前
研友_VZG7GZ应助活人微die采纳,获得10
17秒前
Orange应助科研通管家采纳,获得10
18秒前
打打应助科研通管家采纳,获得10
18秒前
科研通AI2S应助科研通管家采纳,获得10
18秒前
18秒前
啦啦啦完成签到,获得积分20
18秒前
沉静白翠发布了新的文献求助10
18秒前
19秒前
脑洞疼应助Karry采纳,获得10
21秒前
直率的钢铁侠完成签到,获得积分10
22秒前
maoxiaogou完成签到,获得积分10
22秒前
wang5945完成签到 ,获得积分10
22秒前
12334完成签到,获得积分10
23秒前
一个搞不懂晶体学的小牛马完成签到,获得积分20
23秒前
壮观惜文发布了新的文献求助10
25秒前
今后应助Anna爱学习采纳,获得10
26秒前
qazx完成签到 ,获得积分10
27秒前
xmy完成签到,获得积分10
28秒前
28秒前
天天开心完成签到,获得积分10
30秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
Brain and Heart The Triumphs and Struggles of a Pediatric Neurosurgeon 400
Cybersecurity Blueprint – Transitioning to Tech 400
Mixing the elements of mass customisation 400
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3782938
求助须知:如何正确求助?哪些是违规求助? 3328272
关于积分的说明 10235420
捐赠科研通 3043338
什么是DOI,文献DOI怎么找? 1670491
邀请新用户注册赠送积分活动 799731
科研通“疑难数据库(出版商)”最低求助积分说明 759033