Since last couple of decades, the discussion is going on traditional supply chain and cold supply chain. The key difference between both supply chains is the product or materials sensitivity. Usually, cold supply chain used for fragile items/products such as meat, milk, ice cream, tablets, medicine and medical instruments. Undeniably, cold supply chain carry a risk of product expiry due to unsuitable temperature. This research distinguish the difference between traditional supply chain and cold chain in detailed. Researchers used literature reviews method to sum-up the key findings and differences between these supply chains. In the cold supply chain, packaging part is also very costly in terms of delivery to avoid damage, protect from the temperature changes and special handling. As well special packaging increases the cost of storage and limits transportation capacity. On the other hand, modern material handling, the overall operational cost of cold chain warehouses is higher as compare to the normal/regular warehouses. And in the cold environments, electrical devices may lose their functionality. While reliability design in the cold temperatures; reduces the better life by 40 to 50%.