A Yb(OTf)3/PEG-Supported Quaternary Ammonium Salt Catalyst System for a Three-Component Mannich-Type Reaction in Aqueous Media

A one-pot, three-component Mannich reaction of cyclohexanone with aromatic aldehyde and aromatic amine was efficiently catalyzed by Yb(OTf)3/PEG-supported quaternary ammonium salt system in water at room temperature. This reaction afforded the corresponding β-amino carbonyl compounds in good yields with high anti selectivity, and the catalyst system was recyclable.