注射器
胰岛素
lispro胰岛素
普通胰岛素
化学
医学
麻醉
人胰岛素
色谱法
材料科学
内科学
低血糖
精神科
作者
J.C.C. Ung,Ming Hu,Tore Hagerup,R. Keith Campbell
标识
DOI:10.1177/014572179902500209
摘要
The adsorption characteristics and stability profile of an insulin analog, lispro insulin, were evaluated against a recombinant human regular insulin using intravenous infusion sets and syringes.Studies were performed using either 0.9% NaCl or 5% dextrose intravenous injection solution. Effects of container type, infusion rate, product concentration, presence-absence of an in-line filter, and storage condition on release profiles of lispro and human regular insulin infusion solutions were determined.Lispro insulin and m-cresol were chemically stable. Release rates of insulin (both types) were steady after an initial lag time. The lag time was much longer with intravenous bag infusion than with intravenous syringe infusion. A higher product concentration, faster flow rate, and prewash of the infusion tubing were shown to substantially decrease the lag time.The adsorption profile of lispro insulin was the same as that of human regular insulin in both syringes and bags. Use of a load-and-sit prewash scheme may shorten or nearly eliminate the lag time, which in turn may be used to make a more accurate calculation of a patient's dose.
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