医学
紫杉烷
蒽环类
乳腺癌
内科学
环磷酰胺
肿瘤科
闭经
化疗
入射(几何)
妇科
癌症
怀孕
物理
光学
生物
遗传学
作者
Safa Najafi,Gholamreza Esmaeeli Djavid,Neda Mehrdad,Elahe Rajaii,Nasrinsadat Alavi,Aseih Olfatbakhsh,Moslem Najafi,Alireza Bahrami,Kazem Heidari
出处
期刊:Menopause
[Ovid Technologies (Wolters Kluwer)]
日期:2011-02-01
卷期号:18 (2): 208-212
被引量:22
标识
DOI:10.1097/gme.0b013e3181f3e6e7
摘要
In Brief Objective: The objective of our study was to show the impact of different chemotherapy regimens on the incidence of amenorrhea (chemotherapy-induced amenorrhea [CIA]) in premenopausal women of various ages with breast cancer. Methods: This is a follow-up study of 226 premenopausal women with breast cancer who had received one of three chemotherapy regimens: conventional (cyclophosphamide/methotrexate/5-fluorouracil), anthracycline based, and anthracycline-taxane based. They were evaluated for the incidence of CIA in the follow-up clinic of the Iranian Center for Breast Cancer. A statistical analysis using SPSS software was performed, and logistic regression and Cox regression model were used to determine the risk factors for CIA. Results: Of the 226 women with a median age of 40 years (range, 26-56 y) who participated in this study, 154 (68.1%) developed CIA. In 101 (65.6%) of these women, CIA was established. CIA was present in 52.5% of the women who had been treated with conventional regimens (cyclophosphamide/methotrexate/5-fluorouracil), 66.7% of the women who had been treated with anthracycline, and 78.7% of the women who had been treated with anthracycline-taxane. Therefore, the frequency of CIA was significantly higher in the taxane-based chemotherapy group than in the other groups (P = 0.015). Although a slightly higher incidence of CIA in women with hormone-insensitive tumors (estrogen receptor negative and progesterone receptor negative) versus hormone-sensitive tumors (estrogen receptor positive and progesterone receptor positive) who had been treated with combination regimens was observed, no statistically significant difference was found (P = 0.629). Of all of the risk factors that were evaluated in the study, anthracycline-taxane-based regimens (odds ratio, 4.059; 95% CI, 1.6-9.8) and age older than 40 years (odds ratio, 3.5; 95% CI, 1.9-6.6) were the most important factors in the development of CIA. Conclusions: The type of chemotherapy and the age of the woman at the onset of breast cancer are the most important risk factors in CIA. Taxane-based regimens induced more CIA than did other regimens. According to this study, taxane-based chemotherapy regimens and age at diagnosis of more than 40 years are the most important risk factors in chemotherapy-induced amenorrhea in patients with breast cancer.
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