Pharmacokinetics of antipyrine and trimethoprim in pigs with endotoxin‐induced fever

Oral administration of antipyrine or trimethoprim to normal and endotoxin‐pretreated, febrile pigs resulted in pharmacokinetic parameters which were different in the two groups of pigs. The one‐compartment model with first order absorption rate constant can be used to describe the pharmacokinetics of antipyrine and trimethoprim in normal pigs but cannot satisfactorily describe the plasma concentration versus time data in the febrile pigs. The absorption rate and the elimination rate of antipyrine and trimethoprim are reduced in the febrile pigs whereas the volume of distribution is increased.