肺毒性
医学
临床终点
肺
毒性
放射外科
放射科
放射治疗
肺癌
核医学
临床试验
内科学
作者
Heike Peulen,Kristin E. Karlsson,Karin Lindberg,Owe Tullgren,Pia Baumann,Ingmar Lax,Rolf Lewensohn,Peter Wersäll
标识
DOI:10.1016/j.radonc.2011.09.012
摘要
Abstract
Purpose
To assess toxicity and feasibility of reirradiation with stereotactic body radiotherapy (SBRT) after prior lung SBRT for primary lung cancer or lung metastases. Patients and materials
Twenty-nine patients reirradiated with SBRT on 32 lung lesions (11 central, 21 peripheral) were retrospectively reviewed. Median follow-up time was 12months (range 1–97). The primary endpoint was toxicity, secondary endpoints were local control and overall survival time. Toxicity was scored according to the NCI-CTCAE version 3. Results
Grade 3–4 toxicity was scored 14 times in eight patients. Three patients died because of massive bleeding (grade 5). Larger clinical target volumes (CTV) and central tumour localization were associated with more severe toxicity. There was no correlation between mean lung dose (MLD) and lung toxicity. Local control at 5months after reirradiation was 52%, as assessed by CT-scan (n=12) or X-thorax (n=3). A larger CTV was associated with poorer local control. Kaplan–Meier estimated 1- and 2-year survival rates were 59% and 43%, respectively. Conclusions
Reirradiation with SBRT is feasible although increased risk of toxicity was reported in centrally located tumours. Further research is warranted for more accurate selection of patients suitable for reirradiation with SBRT.
科研通智能强力驱动
Strongly Powered by AbleSci AI