生物
肩胛硬蜱
免疫系统
细胞生物学
信号转导
硬蜱
伯氏疏螺旋体
滴答声
微生物学
免疫学
病毒学
抗体
作者
Anya J O'Neal,Nisha Singh,Agustín Rolandelli,Hanna J Laukaitis,Xiaowei Wang,Dana K. Shaw,Bradford A. Young,Sukanya Narasimhan,Shraboni Dutta,Greg Snyder,Sourabh Samaddar,Liron Marnin,L. Rainer Butler,Maria Tays Mendes,Francy E Cabrera Paz,Luisa M. Valencia,Eric J. Sundberg,Erol Fikrig,Utpal Pal,David J. Weber,Joao H. F. Pedra
标识
DOI:10.1073/pnas.2208673120
摘要
The immune deficiency (IMD) pathway directs host defense in arthropods upon bacterial infection. In Pancrustacea, peptidoglycan recognition proteins sense microbial moieties and initiate nuclear factor-κB-driven immune responses. Proteins that elicit the IMD pathway in non-insect arthropods remain elusive. Here, we show that an Ixodes scapularis homolog of croquemort (Crq), a CD36-like protein, promotes activation of the tick IMD pathway. Crq exhibits plasma membrane localization and binds the lipid agonist 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphoglycerol. Crq regulates the IMD and jun N-terminal kinase signaling cascades and limits the acquisition of the Lyme disease spirochete B. burgdorferi . Additionally, nymphs silenced for crq display impaired feeding and delayed molting to adulthood due to a deficiency in ecdysteroid synthesis. Collectively, we establish a distinct mechanism for arthropod immunity outside of insects and crustaceans.
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