化学
转鼓
肟
芳基
钯
烷基
亲核细胞
催化作用
反应性(心理学)
功能群
药物化学
产量(工程)
有机化学
组合化学
冶金
聚合物
替代医学
材料科学
病理
医学
作者
Kosaku Tanaka,Yoshimitsu Hashimoto,Nobuyoshi Morita,Osamu Tamura
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-05
卷期号:24 (49): 8954-8958
被引量:2
标识
DOI:10.1021/acs.orglett.2c03387
摘要
Alkyl aldoximes without a directing group undergo palladium-catalyzed C-H arylation with aryl bromides to afford alkyl aryl ketoximes in moderate to high yields. The reaction of electron-rich aryl bromides and linear oximes proceeded to afford the coupling products in up to 98% yield. This reaction has broad scope and excellent functional group tolerance. Although reactions using hydroxyl oximes as nucleophiles have generally proceeded on the oxygen atom, this reaction selectively proceeds on oxime carbons by taking advantage of the oxime's umpolung properties and Pd reactivity.
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