Wnt信号通路
生物
干细胞
细胞生物学
造血
造血干细胞
LRP6型
免疫学
细胞分化
信号转导
癌症研究
遗传学
基因
作者
Kelsey A Carpenter,Kate E. Thurlow,Sonya Craig,Stephanie Grainger
出处
期刊:Current Topics in Developmental Biology
日期:2023-01-01
卷期号:: 255-279
标识
DOI:10.1016/bs.ctdb.2022.12.001
摘要
Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all cells of the blood and most immune cells. Due to their capacity for unlimited self-renewal, long-term HSCs replenish the blood and immune cells of an organism throughout its life. HSC development, maintenance, and differentiation are all tightly regulated by cell signaling pathways, including the Wnt pathway. Wnt signaling is initiated extracellularly by secreted ligands which bind to cell surface receptors and give rise to several different downstream signaling cascades. These are classically categorized either β-catenin dependent (BCD) or β-catenin independent (BCI) signaling, depending on their reliance on the β-catenin transcriptional activator. HSC development, homeostasis, and differentiation is influenced by both BCD and BCI, with a high degree of sensitivity to the timing and dosage of Wnt signaling. Importantly, dysregulated Wnt signals can result in hematological malignancies such as leukemia, lymphoma, and myeloma. Here, we review how Wnt signaling impacts HSCs during development and in disease.
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