托吡酯
左乙拉西坦
自闭症谱系障碍
奥卡西平
医学
智力残疾
神经发育障碍
拉莫三嗪
精神科
氯硝西泮
自闭症
唑尼沙胺
卡马西平
癫痫
不利影响
儿科
后代
怀孕
内科学
生物
遗传学
作者
Eliza Honybun,Emily Cockle,Charles B. Malpas,Terence J. O’Brien,Frank Vajda,Piero Perucca,Genevieve Rayner
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2024-03-26
卷期号:102 (8): e209175-e209175
被引量:36
标识
DOI:10.1212/wnl.0000000000209175
摘要
The findings of this review support the conclusion that valproate and topiramate use during pregnancy is associated with a significantly increased risk of neurodevelopmental effects on the fetus. Apart from lamotrigine, which seems to be free of adverse neurodevelopmental effects, data for the other ASMs are mixed or inadequate to draw definite conclusions. Further research into the neurodevelopmental effects of prenatal exposure to ASMs, including most newer agents, is much needed.
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