化学
胺化
烷基
卤化物
亚胺
芳基
小学(天文学)
卤素
肟
有机化学
组合化学
催化作用
物理
天文
作者
Lilian Geniller,Marc Taillefer,Florian Jaroschik,Alexis Prieto
标识
DOI:10.1021/acs.joc.3c02431
摘要
We demonstrate that oxime ester derivatives can be used as both a halogen atom transfer (XAT) agent and an imine source under photocatalytic conditions, allowing the radical amination of alkyl halides, resulting in the formation of a broad scope of imines. Hydrolysis of the latter gives direct access to the corresponding primary amines. Mechanistically, the reaction is believed to proceed through the formation of aryl radical intermediates, which are responsible for the activation of alkyl halides via XAT.
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