埃博拉病毒
生物
自噬
埃博拉病毒
病毒学
VP40型
调节器
袋3
丝虫科
mTORC1型
病毒
细胞生物学
PI3K/AKT/mTOR通路
遗传学
信号转导
基因
病毒性疾病
细胞凋亡
副粘病毒科
作者
Jingjing Liang,Marija A Djurkovic,Olena Shtanko,Ronald N. Harty
出处
期刊:Autophagy
[Informa]
日期:2023-02-10
卷期号:: 1-2
标识
DOI:10.1080/15548627.2023.2178781
摘要
Ebola virus (EBOV) and Marburg virus (MARV) are zoonotic, virulent pathogens that cause sporadic and global outbreaks of severe hemorrhagic fever. Reemergence of these filoviruses remains a global public health threat, highlighting the need for novel countermeasures to control and treat future disease outbreaks. The EBOV VP40 matrix protein drives virion assembly and egress. We recently reported that BAG3 and HSPA/HSP70, two central components of chaperone-assisted selective autophagy (CASA), target VP40 for autophagic sequestration and degradation, thereby inhibiting virus egress and spread. In addition, we found that expression of the EBOV glycoprotein (GP) activates MTORC1, the gateway regulator of autophagy. Notably, pharmacological suppression of MTORC1 signaling by rapamycin activates autophagy and blocks filovirus egress. These findings highlight the MTORC1-CASA axis as a regulator of filovirus egress and suggest new opportunities for antiviral development and intervention.
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