Hydrazides: An Important Tool for the Synthesis of 1,3,4-Oxadiazole

Abstract: Hydrazides, derivatives of hydrazine, are widely used in pharmaceuticals, polymers, dyes, herbicides, and as chemical preservatives. A notable application is in synthesizing 1,3,4-oxadiazole, an important aromatic compound with a five-membered heterocyclic ring containing two nitrogen atoms and one oxygen atom. Among the four oxadiazole isomers, 1,3,4-oxadiazole is the most significant, used in drug discovery, pharmaceuticals, and dyes. It is synthesized from various substituted hydrazides or hydrazones using reagents like copper, cobalt, cerium, phosphorus oxychloride, mercury oxide, potassium iodide, triflic anhydride, and carbon disulfide. This study reviews the synthesis methods of 1,3,4-oxadiazole, highlighting the advantages and disadvantages of different catalysts and conditions, providing useful insights for researchers.