Nanosize Controllable Two‐Dimensional (Cu–S) n Metal–Organic Framework Hybrid With Reduced Graphene Oxide by In Situ Microwave and Hydrothermal Synthesis for Electrochemical Neurotransmitter Detection

ABSTRACT We present a groundbreaking technique for controllably synthesizing nanosized semiconductive two‐dimensional (2D) (Cu–S) n metal–organic framework (MOF)/graphene nanocomposites for electrochemical sensing of neurotransmitter 2‐phenethylamine (PEA). The (Cu–S) n MOF size is controlled by graphene oxide proportions, enhancing electrocatalytic activity. The modified electrode exhibits a surface area increase from 0.0639 to 0.1906 cm 2 and impressive limit of detection (0.0156 and 0.004 μM) within linear ranges of 15–200 μM and 1–10 μM, offering exceptional selectivity, reproducibility, and repeatability for biosensing.